Pipeline

Pipeline

A Different Kind of Precision Medicine

We are building a pipeline of targeted cancer therapies by harnessing both our macrocycle platform and our expertise in structure-based design.

Our pipeline consists of innovative investigational therapies designed to address key limitations of existing cancer therapies. We are developing a suite of precision oncology assets, including small molecule, orally available targeted therapies designed to bind to their targets with greater precision and affinity than other kinase inhibitors, and a potentially first-in-class Claudin18.2 antibody-drug conjugate that has the potential to address unmet need in gastrointestinal cancers.

Repotrectinib (ROS1/TRK)1

Discovery
Preclinical
Early Stage Clinical Development
Late Stage Clinical Development
Regulatory Submission

TRIDENT-1: Advanced NSCLC (ROS1) And Solid Tumors (NTRK)

 
 
 
 
 

CARE: Pediatric Advanced Solid Tumors

 
 
 
 
 

TRIDENT-2: KRAS-Targeting Combination

 
 
 
 
 

Elzovantinib (TPX-0022) (MET)1

SHIELD-1: Advanced Solid Tumors

 
 
 
 
 

SHIELD-2: EGFR Combination2

 
 
 
 
 

TPX-0046 (RET)3

SWORD-1: Advanced Solid Tumors

 
 
 
 
 

TPX-0131 (ALK)3

FORGE-1: Advanced NSCLC

 
 
 
 
 

TPX-4589 FORMERLY LM-302 (CLAUDIN18.2)4

Advanced solid tumors

 
 
 
 
 

Discovery Programs3

KRAS G12D

 
 
 
 
 

p21 Activated Kinase

 
 
 
 
 

Multiple GTPase Oncology Targets

 
 
 
 
 

1Turning Point retains worldwide rights, except in Greater China (partnered with ZaiLab)

2Clinical collaboration with EQRx.

3Turning Point retains worldwide rights.

4Turning Point licensed worldwide rights from LaNova Medicines (excluding Greater China and South Korea).