Turning Point Therapeutics Initiates Phase 1 Clinical Study of Tpx-0022, a Novel Met Inhibitor Targeting Advanced Solid Tumors
Patients will be treated with Turning Point’s investigational MET inhibitor, TPX-0022, which has been designed with a unique, compact macrocyclic structure to not only target MET, but also modulate the tumor microenvironment by inhibiting CSF1R and SRC oncogenic signaling to potentially improve therapeutic outcomes.
“We believe the precision therapies we are designing and developing have potential to assist many patients with oncogenic driven cancers, making the start of this new clinical study an important step toward that goal,” said Athena Countouriotis, M.D, chief executive officer of
The Phase 1 study goal is to evaluate the overall safety, tolerability, pharmacokinetics, and preliminary efficacy of TPX-0022 in a standard dose escalation design, followed by dose expansion once the recommended Phase 2 dose is determined.
During dose expansion, the study is planned to have multiple patient cohorts. The cohorts are expected to enroll MET-therapy naïve and pretreated non-small cell lung cancer patients with exon 14 skipping mutations; patients with MET-amplified non-small cell lung, hepatocellular, gastric or gastroesophageal cancer; and patients with other solid tumors harboring MET kinase domain mutations or fusions.
More information about study is available at https://clinicaltrials.gov/ct2/show/NCT03993873
Forward Looking Statements
Statements contained in this press release regarding matters that are not historical facts are “forward-looking statements” within the meaning of the Private Securities Litigation Reform Act of 1995. Such forward-looking statements include statements regarding, among other things, the efficacy, safety and therapeutic potential of the company’s drug candidates, including TPX-0022, the results, conduct and timing of Turning Point Therapeutics’ clinical studies, plans regarding data presentations and future clinical trials. Because such statements are subject to risks and uncertainties, actual results may differ materially from those expressed or implied by such forward-looking statements. Words such as “plans”, “will”, “believes,” “anticipates,” “expects,” “intends,” “goal,” “potential” and similar expressions are intended to identify forward-looking statements. These forward-looking statements are based upon Turning Point Therapeutics’ current expectations and involve assumptions that may never materialize or may prove to be incorrect. Actual results could differ materially from those anticipated in such forward-looking statements as a result of various risks and uncertainties, which include, without limitation, risks and uncertainties associated with Turning Point Therapeutics’ business in general, and the other risks described in Turning Point Therapeutics’ filings with the
Source: Turning Point Therapeutics, Inc.